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寨卡病毒最新產品
寨卡病毒  |  重組蛋白  |    發布者:站內  發布時間:2016-05-16

Zika virus was first discovered after being isolated from a rhesus monkey found in Uganda's Zika Forest. The virus has since been spread from Africa into Asia, and onto the Pacific Islands, before eventually reaching South America. Zika virus is a single-stranded RNA virus of the Flaviviridae family that is transmitted to humans through the bite of an infected Aedes species mosquito, the same mosquitoes that spread dengue and chikungunya viruses. 

The most common symptoms of Zika virus infection are mild fever and skin rash, usually accompanied by conjunctivitis, muscle or joint pain, and general malaise that begins 2-7 days after the bite of an infected mosquito. Although there have been local transmission of Zika virus in the past, recently a large Zika virus outbreak in Brazil has caught world’s attention because for the first time it has linked Zika virus infection to microcephaly through transmission in utero.

 Currently there is no treatment option or vaccine available for Zika virus infection. Diagnosis relies on clinical presentation, recent travel/activities, and lab testing. RT-PCR for the detection of viral RNA during acute phase, and serological testing for detecting Zika-specific antibodies during convalescent phase are the laboratory assays currently employed. The limitation of current laboratory tests present a great challenge to conquer the Zika epidemic because of their specificity, sensitivity, or the prolonged turnaround time.

 To facilitate developing new diagnostic tools and vaccine against Zika virus infection, Immune Tech has geared up our R&D for Zika virus related products. Currently we have the following recombinant proteins available: 

NS1 (Zika virus, Brazil) expressed from 293 mammalian cells, Cat. # IT-006-0063p; 

NS1 (Zika virus, Brazil) expressed from bacterial E.Coli, Cat. # IT-006-0063Ep; 

Envelope Protein (Zika virus, Brazil) expressed from bacterial E.Coli, Cat. # IT-006-0064Ep .

In addition, mouse monoclonal antibodies against above-mentioned Zika proteins are in development and will be available shortly. Please contact us for any further information. 

近期寨卡病毒在巴西大規模的爆發, 引起了全世界的關注。由于許多懷孕婦女在感染寨卡病毒后,其新生兒出現小頭畸形,所以專家第一次將寨卡病毒與新生兒小頭畸形聯系起來。 

寨卡病毒最早在烏干達寨卡叢林的獼恒河猴中被確認,后從非洲一路擴散到亞洲、太平洋島國最后到達南美洲。寨卡病毒屬于黃病毒科,屬單股正鏈RNA病毒,其可通過伊蚊叮咬傳播,這種蚊子還會傳播登革熱病毒和基孔肯亞病毒。 

寨卡病毒感染者一般在伊蚊叮咬后的2-7天表現出如發熱、斑丘疹、結膜炎、肌肉痛、關節痛和全身乏力等較溫和的臨床癥狀。寨卡病毒以前只在發源地傳播,近期卻在巴西大規模的爆發。 

目前世界上沒有特效藥物和疫苗可以用于治療和預防寨卡熱。臨床診斷也只是根據患者的臨床癥狀、近期旅行行程,輔以實驗室檢測結果來進行確診。目前實驗室常用檢測方法有2種,急性發病期使用RT-PCR檢測方法,檢測寨卡病毒RNA;恢復期使用血清學檢測方法,檢測寨卡病毒特異性抗體。由于目前實驗室檢測方法在特異性、敏感性、長期周轉時間上的局限性,導致在攻克寨卡流行病時面臨一個很大的挑戰。 

為幫助寨卡病毒新型診斷方法和疫苗的發展,Immune Tech已研發出寨卡病毒相關產品,可用于科研和診斷領域。目前我們已經獲得下列重組蛋白: 

NS1(寨卡病毒,巴西)經293哺乳細胞表達,貨號Cat. # IT-006-0063p; 

NS1(寨卡病毒,巴西)經大腸桿菌表達,貨號Cat. # IT-006-0063Ep;

Envelope Protein(寨卡病毒,巴西)經大腸桿菌表達,貨號Cat. # IT-006-0064Ep 。

另外,抗上述寨卡病毒重組蛋白的鼠單克隆抗體也正在研發中。若要獲得更多寨卡病毒相關產品信息請與我們聯系。

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